The direct functionalization of C−H bonds is among the most rapid and efficient means to access complex molecules. An inherent challenge associated with such an approach is the regioselectivity of the functionalization due to the ubiquity of C−H bonds in organic compounds. Our group focuses on the development of novel catalytic methods which address this issue while avoiding the requirement for unproductive substrate modifications.
While it is well-known that a large number of biologically active compounds are chiral and that both enantiomers often have different effects on the patient, very few pharmaceuticals are commercialized in their enantiopure form. This issue stems from the lack of efficiency of existing approaches that allow access to pure enantiomers. Our group seeks to further streamline these processes via the design of superior chiral catalysts.
Organometallic complexes, which are metal complexes possessing at least one metal-carbon bond, constitute some of the most commonly found species in modern catalysis, often existing as high-energy intermediates. Our group works toward understanding the effect of the structure of these complexes on their reactivity in order to achieve an optimal activity in various catalytic contexts.
Green / Sustainable Chemistry
In recent years, the growing concerns about climate change and its direct relation with industrial processes have transformed the way people think about the production of their goods. In addition to the extensive use of catalysis as a superior solution to this problem, our group strives to develop more sustainable methodologies employing reagents and solvents with reduced toxicities, requiring fewer energy and producing less waste.